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Wetting time, in vitro disintegration thinks about, Curve fitting examination.
Blood level curves for im and sustained release dosage form. Dobrinska MR, Welling PG. Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release ER, XR, XL dosage) or to a specific target in the body (targeted-release dosage). Dose of the drug should not be too large, as a larger dose is to be incorporated into sustained release dosage form.
The plasma concentration-time curve (blood level curve) is the focal point of. Intramuscular / Subcutaneous route:. Riods of sub-therapeutic drug blood levels or those.
In controlled release dosage form the blood level is evenly maintained. The areas under the curves of the plasmalevel vs time forthe threedosage forms were with· in 9 percent of each other. Find the latest articles and preprints.
To be a good candidate for sustained release dosage form. Calculation of amount of drug required for designing a sustained release dosage form. Most of sustained release dosage form follows the mechanism of diffusion, dissolution or combination of both, to produce slow release of drug at predetermined rate.
Blood levels from a sustained-release dosage form. The method is based on assumption that two dosage forms that exhibit superimposable plasma level-time profile in a group of subjects should result in identical therapeutic activity. Blood levels from a sustained-release dosage form.
These data indicate thata sig nificant reduction in ftuctuations of the plasma level of theophylline was achieved with the two sustained-release dosage forms, compared to the elixir. Maximum 2ml or 2 gm can be administered through this route. Duration of action can be prolonged from 24hours to 12 months.
Journal of Pharmaceutical Sciences, 01 Oct 1975, 64(10):. Hypothetically, a sustained release dosage form should release the drug by a zero-order mechanism which maintains drug plasma level time similar to intravenous infusion. Potential advantage of sustained release dosage form Avoid patient’s compliance problem due to Blood level oscillation characteristics of osage form maintained.
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